Claim Review: Repeated COVID-19 mRNA Vaccinations and Immune System Functionality in Older Adults

Infowars claims that a study published in September indicated that repeated inoculation with mRNA Covid vaccinations reduce the functionality of the immune systems of old people. The study in question, titled 'Repeated COVID-19 mRNA vaccination results in IgG4 class switching and decreased NK cell activation by S1-specific antibodies in older adults,' was published in Immunity & Ageing. The study found that older adults produce antibodies with reduced functional capacity upon repeated COVID-19 mRNA vaccination, similar to younger individuals.

The specific mechanism of immune system reduction is increased levels of IgG4, a subclass of immunoglobulin which can result in a reduction of immune system function. The researchers analyzed patients aged 65 to 83-years-old for one month after their fifth Covid injection and compared their immune system effects with a younger group aged 18 to 47-years-old for one month after their third Covid injection. The researchers assessed the development of SARS-CoV-2 spike S1-specific IgG subclass levels in the older adults vs the younger adults.

The study concluded that older adults, like younger individuals, are inclined to develop IgG4 responses upon repeated COVID-19 mRNA vaccination and that increased IgG4 levels associate with a relative reduction in Fc-mediated effector functionality. However, the study does not conclusively prove that this leads to a significant reduction in overall immune system functionality. The study's authors emphasize the need for additional research to better understand the mechanisms underlying these responses and their potential implications for vaccine effectiveness.

It is important to note that the study does not suggest that the vaccines are ineffective or that older adults should not receive them. Instead, it highlights the complex nature of the immune response to vaccination and the need for continued research to optimize vaccination strategies.

In conclusion, the claim that repeated COVID-19 mRNA vaccinations reduce the functionality of the immune systems of older adults is not fully supported by the study. While the study shows an increase in IgG4 levels, which are associated with reduced Fc-mediated effector functionality, it does not conclusively prove that this leads to a significant reduction in overall immune system functionality. Further research is needed to understand the implications of these findings on vaccine effectiveness.

For more information, you can read the study here.